My most memorable vacation would have to be my honeymoon :) DH and I have actually gone on many great vacations, but that one was the best!
We went on a Carnival Cruise to the Bahamas! It was absolutely amazing :) We didn't get to do that much on one of the islands that we stopped at b/c they had recently been hit by a hurricane, but we still got to do some fun stuff--including seeing the famous Marching Flamingos at a wildlife conservatory thing there. It was really neat.
The best part, for me, was actually being on the ship. I loved that it was all-inclusive and that there were so many things to do just right there on the ship. We were in awe :)
It was also exciting because it was something that I never dreamed I would have the opportunity to do. We are already looking forward to going on another cruise for an anniversary one day.
It was also memorable because it included a lot of our getting-to-know each other times, since we didn't live together or anything like that before marriage :)