I take my photos in natural light standing directly over the page (being careful not to cast shadows!). I don't like using a flash.
Sometimes it helps if the layout is on a table in front of a window with good light.
I usually take the pic in the macro setting and then I crop, adjust lighting if necessary, and sharpen in Picasa or PSE.....
I prop mine up on a turned-out binder (rings outside, one side flat on the desk, another propped upright from behind ) - gives a flat solid stand for the layout. OTT/natural white light nearby (not directly onto the page but reflected). set the camera to landscape mode, it will keep the entire layout in focus. shoot away. then fix everything in the editing software - straighten the edges, crop if needed, auto fix color and exposure, set neutrals (if shooting indoors in yellow light or if the whites seem off).
When my flat-screen monitor is off (black), I prop my LO on the little lip at the bottom of the screen. The main thing I try to do is hold the camera so the top and a side are pretty straight with the sides of the lens viewer. This makes for less straightening in the editing.
A small tripod helps for steadiness, or use the self-timer camera function. Set it for 10 sec., then hold the camera and don't breathe :>) This gets away from the blur that can happen when the shutter button is pushed.
Then I crop, adjust lighting and whatever else is needed. I don't post many LOs just because once I'm done with the LO, I don't want to spend the time getting a good picture of it. Later I regret it and end out spending an hour or two taking pictures of a bunch of LOs. Even if I don't post them, I want them for my own files as back-up.~Judy