I haven’t used any spray adhesive on my mat yet, but I have used a few other wet glues: Zip Dry, Ranger Matte Medium, Scotch white glue, and other white craft glues. Even Glossy Accents! I have been able to remove them all, whether they were still wet, or if they dried, using hand sanitizer. The Scrapbook.com mat is always on my craft table. I am planning to purchase at least one more. I love this silicone mat.