Sure you can use the Big Shot with your M-Bossibilities. Difference is that you DO NOT use a bottom plate in your Big Shot sandwich (platform on fully closed, paper in embossing folder, top plate). You can see a really good video on YouTube by typing Spellbinders M-Bossabilities, Sizzix Big Shot & Memento by Scrapbooking Made Simple. Happy cranking.
P.S. 3-D M-Bossibilities is the same, except they recommend you use a lighter weight paper.
By: Sue Stanger